NeuroToxicology: The role of carbon monoxide in aerotoxic syndrome

Aircraft engine oil and hydraulic fluid can degrade at temperatures above 300 °C, and generate CO when in contact with hot metal surfaces.

The most common signs and symptoms of chronic carbon monoxide (CO) intoxication are nonspecific and include headache, dizziness, lethargy, cognitive impairment, and confusion.

In at least 129 of 888 (14.5%) flights, CO levels were ranging from 13-60 ppm.

Guidelines for CO-exposure limits established at sea level may not be suitable for aviation circumstances.

An occupational exposure limit of 5 ppm (8 hr TWA) for aircrew is recommended.